Synthesis of Some New Substituted Isatin Derivatives with Possible Antipyretic Activity
Roopali Tandon, Associate Professor, Deptt. of Chemistry, Bareilly College, Bareilly.
A.K. Gupta, Asstt. Professor, Deptt. of Chemistry, KCMT, Bareilly.
A.K. Agarwal, Retd. Associate Professor, Deptt. of Chemistry, Bareilly College, Bareilly.
S.C. Mehra, Retd. Professor, Deptt. of Chemistry, Bareilly College Bareilly.
DOI: 10.70650/rvimj.2025v2i4001
DOI URL: https://doi.org/10.70650/rvimj.2025v2i4001
Published Date: 03-04-2025 Issue: Vol. 2 No. 4 (2025): April 2025 Published Paper PDF: Download E-Certificate: Download
DOI: 10.70650/rvimj.2025v2i4001
DOI URL: https://doi.org/10.70650/rvimj.2025v2i4001 Published Date: 03-04-2025 Issue: Vol. 2 No. 4 (2025): April 2025 Published Paper PDF: Download E-Certificate: Download
Abstract: Substituted isatin derivative have been prepared by treating substituted aromatic amines with hydroxylamine hydrochloride with chloralhydrate in presence of sodium sulphate to form 2-hydoxyimino-N-p-tolyacetamide which on reaction with conc. H2SO4 to give 5-subsituted isatin which when condensed with 2-amino-4-Aryl thiazole to yield indolin-2-one derivatives with possible anti pyretic activity.
Keywords:Synthesis, Aromatic amines, Isatin, Antipyretic activity.
